Elise (Angelina Jolie) randomly sits next to an American tourist, Frank (Johnny Depp), on a Venice-bound train. The police have been following Elise for over two years waiting for her to contact her lover, who embezzled over $2 Billion from a mobster. The British Economic Police want to collect its share (taxes) of over $775 Million to be paid on this money. Frank, a math teacher, and Elise must evade the police, and also the mobster who's money was stolen. The storyline is not complicated; the mobsters money man steals a large amount of his money, and he is now on the run for his life, plus the police want him too. The police don't know what he looks like, so they need Elise to identify him. There is a story twist at the end.